The Complexity of Biology
Despite huge advances in the ‘omics’ technologies (genomics, transcriptomics, proteomics, metabolomics), how cells operate in extremely complex integrated systems, remains shrouded in mystery. Our future success in treating serious diseases will depend on our ability to illuminate and decipher this complex biology.
High-Resolution Dynamic Modelling Platform
Oppilotech have developed a proprietary High-Resolution Dynamic Modelling platform that produces detailed computational simulations of cellular processes which can then be compared to traditional wet-lab experiments in order to validate or question the accuracy of the computer model. This process can occur thousands of times in a machine learning cycle. The end result is a model which is accurate, reliable; reveals new biological processes and novel approaches for therapeutic interventions.
One of the most important challenges in drug discovery is identifying the most relevant biological target to aim the therapeutic efforts against. The complex biology within cells often surprise scientists and can turn a promising drug target into a redundant one further down the development path.
Oppilotech are applying their High-Resolution Dynamic Modelling platform to reveal new biology, identify viable drug targets AND develop molecules that modulate the identified targets. We have a proven track record in successfully doing this and are generating our own pipeline of first-in-class drug discovery programmes.
Our high resolution modelling is conducted on our COMET (Computationally Optimised Mechanistically Evaluated Targets) platform. Built on a combination of text mined publicly available data and +10 years of wet lab in house generated genomic modelling data, this platform allows us to map biology at unprecedented levels of detail around a chosen pathway/target. Giving us high resolution, mechanistic insights, not just highlighting excellent novel drug targets, but also explaining why they are good.
Unlike statistical or associative models, our High-Resolution Dynamic modelling aims to throw light on the mechanistic processes within cells.
A more detailed understanding of these mechanisms will result in a closer representation of actual cellular behaviour and therefore superior accuracy in drug target selection.
Applications of the High-Resolution Dynamic Modelling Platform
The High-Resolution Dynamic Modelling Platform is being applied to create a whole cell model of the bacterium E.coli
We are utilising the model to identify viable targets and to develop first-in-class antibacterial drugs to address the looming antibacterial resistance crisis.
Snapshot of biosynthesis of peptidoglycan– a component of the outer envelope of bacteria based on our High-Resolution Dynamic Modelling. The dots represents enzymes, substrates and metabolites involved in the biosynthesis of peptidoglycan. The yellow dots represents the peptidoglycan dimers being formed and flipped into the periplasm space.
We are also applying our High-Resolution Dynamic Modelling Platform to model pathways in mammalian cells implicated in cancer (MAP Kinase signalling and DNA Damage Response pathways) and inflammation.
The first-in-class targets that are being identified are forming the basis for exciting novel drug discovery programmes in the oncology, antibacterial and inflammation fields.
We are improving our Platform and are open to partnerships with groups wanting to apply our modelling approach on pathways they are working on in the mammalian and antibacterial fields. Please contact us.
Our Microbiology Laboratory Services
We can also use our technology and expertise to offer platform mapping services and anti-infective microbiology testing service.